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JAPAN NANONET BULLETIN - 74th Issue - July 6, 2006

YOUNG RESEARCHERS’ INTRODUCTION

Masaru TANAKA
Associate Professor, Nanomaterial Laboratory, Nanotechnology Research Center, Research Institute for Electronic Science, Hokkaido University

Design and preparation of nano-biointerfaces by self-organization

(Issued in Japanese: July 6, 2005)

The design of nano and microstructures by self-organization is a key area of research in the search for new materials and has a variety of potential applications in “Nanobiotechnologies”. We investigate highly regular porous films (Fig.1) and 3-D patterned surfaces (Fig.2) formed by a solution casting technique in humid air. Condensation of water from the air due to evaporation and cooling occurred when a water-immiscible solvent was used. Self-packed and mono-dispersed water droplets, formed on the solution surface, act as a temporary template of pores. The pore size can be controlled in the range from 100 nm to 50 μm by changing the casting conditions. Unlike other template-based, or lithographic methods, the advantage of this method is ease with which such patterned surfaces can be created using various materials. Self-organized porous films with different pore sizes were prepared in order to investigate the influence of pore size on cell behavior. Surfaces have a strong influence on cell morphology, proliferation, differentiation, cytoskeleton and extra cellular matrix production profiles. The structure of water adsorbed onto polymer surfaces greatly affected the cell behavior. Films with well-ordered nanostructures can be used for biomedical, photonic and electronic materials.

In particular, we work on the following topics:

Masaru TANAKA
Masaru TANAKA
Associate Professor, Nanomaterial Laboratory, Nanotechnology Research Center, Research Institute for Electronic Science, Hokkaido University
 
1994
~1996		Graduate School of Hokkaido University
1996
~2000		Terumo Corporation, Research & Development Center, Ashitaka Factory, Fujinomiya Factory
2000
~2004		Molecular Device Laboratory, Research Institute for Electronic Science, Hokkaido University
2001
~2005		Researcher in the field of “Organization and Function“, Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST)
2004
~2006		Associate Professor, Biomaterials / Tissue Engineering Research Group, Creative Research Initiative "Sousei" (CRIS), Hokkaido University
2006
~present		Associate Professor, Nanomaterial Laboratory, Nanotechnology Research Center, Research Institute for Electronic Science, Hokkaido University
 
Award
2002Young Scientist Award for the Presentation of an Excellent Paper; The Japan Society of Applied Physics
2003Award for the Presentation of an Excellent Paper; The Chemical Society of Japan
2004Award for the Presentation of an Excellent Paper; The Japanese Society for Regenerative Medicine
2005Award for Encouragement of Research in Polymer Science; The Society of Polymer Science, Japan
 
E-mail:


Fig.1
Fig.1 Self-organized porous film.
a) Whole image of a film on glass substrate. b) Whole image of a self-supported film. c) Optical microscope image. d) SEM image. e) Laser diffraction pattern from the film.

Fig.2
Fig.2 Self-organized 3-D patterns.
a) Triple-layered film b) Double-layered film c)Arrays of polymer nano-pillars. d) Tilted nano-pillar

Relevant papers
  1. Tanaka, M., Takebayashi, M., Miyama, M., Nishida, J. & Shimomura, M.
    Design of Novel BioInterfaces (II) -Fabrication of self-organized porous polymer film with highly uniform pores-
    Bio-Med. Mater. Eng. 14, 439-446 (2004).
  2. Tanaka, M. & Mochizuki, A.
    Effect of water structure on blood compatibility -Thermal analysis of water in poly(meth)acrylate-
    J. Biomed. Mater. Res. 68A, 684-695 (2004).
  3. Tsuruma, A., Tanaka, M., Fukushima, N. & Shimomura, M.
    Morphological changes in neurons by self-organized patterned films
    e-J. Surf. Sci. Nanotech. 3, 159-164 (2005).
  4. Yabu, H., Takebayashi, M., Tanaka, M. & Shimomura, M.
    Superhydrophobic and Lipophobic Properties of Self-Organized Honeycomb and Pincushion Structures
    Langmuir 21, 3235-3237 (2005).
  5. Tanaka, M., Nishikawa, K., Okubo, H., Kamachi, H., Kawai, T., Matsushita, M., Todo, S. & Shimomura, M.
    Control of hepatocyte adhesion and function on self-organized honeycomb-patterned polymer film Colloids
    and Surfaces A: Physicochemical and Engineering Aspects, in press.